Pulmonary infection of adult white mice with the TE 55 strain of trachoma virus.
نویسندگان
چکیده
Thygeson & Nataf (1958) stated, ‘It is now generally agreed that only primates are susceptible to experimental infection with trachoma virus ’. Since then Giroud, Renoux & Nataf (1958) have reported pulmonary hepatization in mice after intranasal inoculation of material from trachomatous conjunctivae; Hurst & Reeve (1960) reported passage of the TE55 strain in mouse brain; and Bernkopf (1959) reported the susceptibility of young mice to infection after intranasal inoculation with the TE55 and Dari strains of trachoma virus. Bell, Snyder & Murray (1959) showed a rapid toxic effect of certain strains after intravenous injection into adult mice, but this phenomenon did not depend upon the growth of virus. These workers were chiefly interested in the mouse either as a means of growing the virus or as an experimental system for neutralization tests. For the second purpose a lethal effect of intranasal inoculation was required. Bernkopf (1959) found that 9-day-old mice were highly susceptible, three-week old mice much less susceptible, and sixweek old mice insusceptible to intranasal inoculation with the TE55 strain. Insusceptibility in this sense means that the mice did not die. The experiments reported here were made to examine the effects of intranasal inoculation of older, and therefore ‘insusceptible’ mice with the TE55 strain of trachoma virus. It was considered that these mice would either be totally insusceptible, in which case the system could be studied as an example of host resistance developing with age, or partly susceptible, in which case lesions would develop which would not lead to death, and would presumably resolve. Preliminary observations showed that older mice were, in fact, partly susceptible, and that they would provide a system in which the pathogenesis and immunology of trachomatous infection could be studied in a non-primate host.
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عنوان ژورنال:
- Journal of general microbiology
دوره 30 شماره
صفحات -
تاریخ انتشار 1963